The Benefits of CBD

The Benefits of CBD

Oct 26th 2019

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THE BENEFITS OF CBD

We at Chrysalis Nutraceuticals, Inc. (“Chrysalis™”) take your trust very seriously. As many of you know, we are prohibited by the Food and Drug Administration (FDA) from making certain kinds of statements about CBD and CBD products. The statements we make regarding our products have not been reviewed or approved by the FDA and the products have not been evaluated for their efficacy. Because there are companies out there offering CBD oils and products that do not contain the CBD as represented or they are being hawked as a miracle cure for every ailment on the planet, we actually support the FDA’s position on this.

We can and do tell you that these products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your healthcare professional about potential interactions or any other possible complications before using any product. The Federal Food, Drug, and Cosmetic Act requires us to provide you with this notice.

Although we’re proud of the people we’ve helped thus far, Chrysalis Nutraceuticals, Inc. (“Chrysalis™”) is not to be held liable for any medical claims made by customer testimonials. These testimonials, as great as they are, have not been confirmed by FDA-approved research.

If you chose to use any of these products improperly, Chrysalis™ assumes no responsibility. We always recommend that you consult with a qualified health professional when you decide to pursue a treatment plan for any disease or condition. If you’re pregnant, nursing, chronically ill, elderly or under the age of 18 it’s especially critical that you discuss the use of our products with a physician prior to consuming. We require that you be 18 years or older before you buy any of our products or spend time at our website. Our website is only intended to provide general information regarding our products and it should not be considered as medical advice or instruction.

Chrysalis and its products have been and will always be science-based. Although hemp has been with us since before recorded history, only in the last fifty years has it gone from relative obscurity to being intensely researched. Due to social and possibly pharmacology company influence, CBD’s genetic connection to marijuana has inhibited much of the scientific study that would likely have developed more rapidly over the years.

There is much more to learn about CBD and how and why humans react to it the way they do. The body’s endocannabinoid system (see our Endocannabinoid System article) is a relatively recent discovery and the exact mechanisms of that system have yet to be fully determined. The interaction of the Endocannabinoid System is so critical to the proper functioning of the entire body, it is reasonable to expect that supporting the functions of that system will have many positive effects. Although the body of research has grown exponentially over the last decade, it may take many more decades to fully understand all the effects of CBD.

Because of its scientific orientation, Chrysalis has focused only on the existing body of research in the development of its products. While anecdotes and exclamations about the benefits of CBD are exciting, research and science are much more reliable for this purpose.

The research and scientific evidence supports a number of possible benefits and CBD has become incredibly popular as a natural remedy for those seeking relief from some very common ailments. The fact that you’re reading this suggests you’ve probably already heard about many of the benefits as depicted in this infographic: 

As much as we’d like to include the tens of thousands of pages of CBD research papers, white papers, books, manuscripts, test results, testimonials and other documents from the Chrysalis Research Library that were studied and applied during the development of our CBD products, it’s simply not practical here. For those of you sincerely interested in learning more about CBD we have included several potential benefits along with references to some of the research (see below) so that you can pursue your own studies further if you like. For the rest of you, you can take heart in knowing that Chrysalis is a science-based CBD product company and to the best of our ability, we’ve done the diligent work required to bring you the very best CBD products available today.

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Benefits of CBD- Related Topics and References:

Based on the following studies (and many others not included), there may be beneficial results when including CBD in a program to help manage certain conditions:

Pain:

J. Russell Reynolds, “On Some of the Therapeutical Uses of Indian Hemp,” in Archives of Medicine, vol. 2 (London, 1859), 154.

R. Greco, V. Gasperi, M. Maccarrone, and C. Tassorelli, “The Endocannabinoid System and Migraine,” Experimental Neurololgy 224, no. 1 (2010): 85–91. doi:10.1016/j.expneurol.2010.03.029.

Ethan Russo and Andrea Hohmann, “Role of Cannabinoids in Pain Management,” in Comprehensive Treatment of Chronic Pain by Medical, Interventional and Integrative Approaches, ed. Timothy R. Deer et al. (New York: Springer, 2013), 181–197.

E. B. Russo, “Cannabinoids in the Management of Difficult to Treat Pain,” Journal of Therapeutics and Clinical Risk Management 4, no. 1 (2008): 245–259.

S. Maione, F. Piscitelli, L. Gatta, D. Vita, L. De Petrocellis, E. Palazzo, V. de Novellis, and V. Di Marzo, “Non-psychoactive Cannabinoids Modulate the Descending Pathway of Antinociception in Anaesthetized Rats through Several Mechanisms of Action,” British Journal of Pharmacology 162, no. 3 (2011): 584. doi:10.1111/j.1476-5381.2010.01063.x.

Pain treatment in lieu of opioids:

W. Xiong, T. Cui, K. Cheng, F. Yang, S. R. Chen, D. Willenbring, Y. Guan, H. L. Pan, K. Ren, Y. Xu, and L. Zhang, “Cannabinoids Suppress Infammatory and Neuropathic Pain by Targeting α3 Glycine Receptors,” Journal of Experimental Medicine 209, no. 6 (2012): 1121–1134. doi:10.1084 /jem.20120242.

M. DeGeorge, E. Dawson, P. Woster, L. Burke, and K. Bronstein, An Analysis of the Association between Marijuana Use and Potential Nonadherence in Patients Prescribed Hydrocodon (Baltimore: Ameritox, 2013), www.ameritox .com/wp-content/uploads/Ananalysisoftheassociationbetweenmarijua nauseandpotentialnonadherence_AAPM2013.pdf.

Anxiety and Stress:

G. A. Grierson, “The Hemp Plant in Sanskrit and Hindi Literature,” Indian Antiquary (September 1894): 260–262.

A. R. Schier, N. P. Ribeiro, A. C. Silva, J. E. Hallak, J. A. Crippa, A. E. Nardi, and A. W. Zuardi, “Cannabidiol, a Cannabis sativa Constituent, As an Anxiolytic Drug,” Revista Brasileira de Psiquiatri 34, suppl. 1 (2012): S104–S110. PubMed PMID: 22729452.

R. J. Bluett, J. C. Gamble-George, D. J. Hermanson, N. D. Hartley, L. J. Marnett, and S. Patel, “Central Anandamide Deficiency Predicts Stress Induced Anxiety: Behavioral Reversal through Endocannabinoid Augmentation,” Translational Psychiatry 8, no. 4 (2014): e408. doi:10.1038/ tp.2014.53.

A. C. Campos, Z. Ortega, J. Palazuelos, M. V. Fogaça, D. C. Aguiar, J. Díaz-Alonso, S. Ortega-Gutiérrez, H. Vázquez-Villa, F. A. Moreira, M. Guzmán, I. Galve-Roperh, and F. S. Guimarães, “The Anxiolytic Effect of Cannabidiol on Chronically Stressed Mice Depends on Hippocampal Neurogenesis: Involvement of the Endocannabinoid System,” International Journal of Neuropsychopharmacology 16, no. 6 (2013): 1407–1419. doi:10.1017/S1461145712001502.

Depression and Mood Disorders:

McGill University, “Cannabis: Potent Anti-depressant In Low Doses, Worsens Depression At High Doses,” ScienceDaily, October 24, 2007.

M. N. Hill, C. J. Hillard, F. R. Bambico, S. Patel, B. B. Gorzalka, and G. Gobbi, “The Therapeutic Potential of the Endocannabinoid System for the Development of a Novel Class of Antidepressants,” Trends in Pharmacological Sciences 30, no. 9 (2009): 484–493. doi:10.1016/j.tips.2009.06.006.

R. Linge, L. Jiménez-Sánchez, L. Campa, F. Pilar-Cuéllar, R. Vidal, A. Pazos, and A. Adell Díaz, “Cannabidiol Induces Rapid-Acting Antidepressant-Like Effects and Enhances Cortical 5-HT/Glutamate Neurotransmission: Role of 5-HT1A Receptors,” Neuropharmacology 103 (2016): 16. doi:10.1016/j.neuropharm.2015.12.017.

Samir Haj-Dahmane and Roh-Yu Shen, “Endocannabinoid Signaling and the Regulation of the Serotonin System,” in Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders, ed. Elisabeth J. Van Bockstaele (New York: Springer, 2013), 239–254. doi:10.1007/977-4614-7940-6_11.

M. N. Hill, C. J. Hillard, F. R. Bambico, S. Patel, B. B. Gorzalka, and G. Gobbi, “The Therapeutic Potential of the Endocannabinoid System for the Development of a Novel Class of Antidepressants,” Trends in Pharmacological Sciences 30, no. 9 (2009): 484–493. doi:10.1016/j.tips.2009.06.006.

C. H. Ashton, P. B. Moore, P. Gallagher, and A. H. Young, “Cannabinoids in Bipolar Affective Disorder: A Review and Discussion of Their Therapeutic Potential,” Journal of Psychopharmacology 19, no. 3 (2005): 293–300.

A. Zuardi, J. Crippa, S. Dursun, S. Morais, J. Vilela, R. Sanches, and J. Hallak, “Cannabidiol Was Ineffective for Manic Episode of Bipolar Affective Disorder,” Journal of Psychopharmacology 24, no. 1 (2010): 135– 137. doi:10.1177/0269881108096521.

Abir T. El-Alfy, Kelly Ivey, Keisha Robinson, Safwat Ahmed, Mohamed Radwan, Desmond Slade, Ikhlas Khan, Mahmoud ElSohly, and Samir Ross, “Antidepressant-Like Effect of ∆9-tetrahydrocannabinol and Other Cannabinoids Isolated from Cannabis sativa,” Journal of Pharmacology, Biochemistry and Behavior 95, no. 4 (June 2010): 434–442.

A. R. de Mello Schier, N. P. de Oliveira Ribeiro, D. S. Coutinho, S. Machado, O. Arias-Carrión, J. A. Crippa, A. W. Zuardi, A. E. Nardi, and A. C. Silva, “Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa,” CNS Neurol Disorders – Drug Targets 13, no. 6 (2014): 953–960.

Sleep disorders:

E. Murillo-Rodríguez, D. Millán-Aldaco, M. Palomero-Rivero, R. Mechoulam, and R. Drucker-Colín, “The Nonpsychoactive Cannabis Constituent Cannabidiol Is a Wake-Inducing Agent,” Behavioral Neuroscience 122, no. 6 (2008): 1378–1382.

D. W. Carley, S. Paviovic, M. Janelidze, and M. Radulovacki, “Functional Role for Cannabinoids in Respiratory Stability during Sleep,” Sleep 25, no. 4 (2002): 391–398. PubMed PMID: 12071539.

Bharati Prasad, Miodrag G. Radulovacki, and David W. Carley, “Proof of Concept Trial of Dronabinol in Obstructive Sleep Apnea,” Frontiers in Psychiatry 4 (2013): 1.

E. B. Russo, G. W. Guy, and P. J. Robson, “Cannabis, Pain, and Sleep: Lessons from Therapeutic Clinical Trials of Sativex, a Cannabis-Based Medicine,” Chemistry and Biodiversity 4, no. 8 (2007): 1729–1743.

M. H. N. Chagas, A. L. Eckeli, A. W. Zuardi, M. A. Pena-Pereira, M. A. Sobreira-Neto, E. T. Sobreira, M. R. Camilo, M. M. Bergamaschi, C. H. Schenck, J. E. C. Hallak, V. Tumas, and J. A. S. Crippa, “Cannabidiol Can Improve Complex Sleep-Related Behaviours Associated with Rapid Eye Movement Sleep Behaviour Disorder in Parkinson’s Disease Patients: A Case Series,” Journal of Clinical Pharmacy and Therapeutics 39 (2014): 564–566. doi:10.1111/jcpt.12179.

Neurological communication between the brain and body for better health:

Bradley E. Alger, “Getting High on the Endocannabinoid System,” Cerebrum: The Dana Forum on Brain Science (2013): 14.

Brain health:

Andras Bilkei-Gorzo, “The Endocannabinoid System in Normal and Pathological Brain Ageing,” Philosophical Transactions of the Royal Society of London 367, no. 1607 (2012): 3326–3341. doi:10.1098/rstb.2011.0388.

J. Fernández-Ruiz, O. Sagredo, M. R. Pazos, C. García, R. Pertwee, R. Mechoulam, and J. Martínez-Orgado, “Cannabidiol for Neurodegenerative Disorders: Important New Clinical Applications for This Phytocannabinoid?” British Journal of Clinical Pharmacology 75, no. 2 (May 25, 2012): 323–333.

Aging related brain and nerve-related disease including Alzheimer’s and neuropathy:

Gary L. Wenk, “Animal Models of Alzheimer’s Disease,” Animal Models of Neurological Disease I (1992): 29–64, doi:10.1385/0-89603-208-6:29.

Obesity:

Yann LeStrat and Bernard Le Foll, “Obesity and Cannabis Use: Results From 2 Representative National Surveys,” American Journal of Epidemiology 174, no. 8 (2011): 929–933. doi:10.1093/aje/kwr200.

H. J. Parray and J. W. Yun, “Cannabidiol Promotes Browning in 3T3-L1 Adipocytes,” Molecular and Cellular Biochemistry 416 (2016): 131–139.

Development of pre-diabetic conditions:

E. A. Penner, H. Buettner, and M. A. Mittleman, “Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults,” American Journal of Medicine 126 (2013): 583–589.

Diabetes:

L. Weiss, M. Zeira, S. Reich, M. Har-Noy, R. Mechoulam, S. Slavin, and R. Gallily, “Cannabidiol Lowers Incidence of Diabetes in Non-obese Diabetic Mice,” Autoimmunity 39, no. 2 (2006): 143–151.

Abigail Klein Leichman, “Cannabis Extract to Be Used to Treat Diabetes,” Israel 21c, April 21, 2015, www.israel21c.org/cannabis-extract -to-be-used-to-treat-diabetes/.

Inflammation leading to atherosclerosis:

Mauro Maccarrone, Itai Bab, Tamás Bíró, Guy A. Cabral, Sudhansu K. Dey, Vincenzo Di Marzo, Justin C. Konje, George Kunos, Raphael Mechoulam, Pal Pacher, Keith A. Sharkey, and Andreas Zimmer, “Endocannabinoid Signaling at the Periphery, 50 Years after THC,” Cell: Trends in Pharmacological Science 36, no. 5 (May 2015): 277–296.

Sabine Steffens and Francois Mach, “Cannabinoid Receptors in Atherosclerosis,” Current Opinion in Lipidology 17, no. 5 (2006): 519–526. doi:10.1097/01.mol.0000245257.17764.b2.

Atherosclerosis (as a precursor to heart disease, stroke and many other conditions):

Sabine Steffens, Niels R. Veillard, Claire Arnaud, Graziano Pelli, Fabienne Burger, Christian Staub, Andreas Zimmer, Jean-Louis Frossard, and François Mach, “Low Dose Oral Cannabinoid Therapy Reduces Progression of Atherosclerosis in Mice,” Nature 434 (2005): 782–786.

Francois Mach and Sabine Steffens, “The Role of the Endocannabinoid System in Atherosclerosis,” Journal of Neuroendocrinology 20, no. S1 (2008): 53–57. doi:10.1111/j.1365-2826.2008.01685.x.

Heart attack:

Ronen Durst, Haim Danenberg, Ruth Gallily, Raphael Mechoulam, Keren Meir, Etty Grad, Ronen Beeri, Thea Pugatsch, Elizabet Tarsish, and Chaim Lotan, “Cannabidiol, A Nonpsychoactive Cannabis Constituent, Protects against Myocardial Ischemic Reperfusion Injury,” American Journal of Physiology – Heart and Circulatory Physiology 293, no. 6 (2007): H3602–H3607. doi:10.1152/ajpheart.00098.2007.

John C. Ashton and Paul F. Smith, “Cannabinoids and Cardiovascular Disease: The Outlook for Clinical Treatments,” Current Vascular Pharmacology 5, no. 3 (2007): 175–184. doi:10.2174/157016107781024109.

Cancer risks:

Gabriella Aviello, Barbara Romano, Francesca Borrelli, Raffaele Capasso, Laura Gallo, Fabiana Piscitelli, Vincenzo Di Marzo, and Angelo A. Izzo, “Chemopreventive Effect of the Non-psychotropic Phytocannabinoid Cannabidiol on Experimental Colon Cancer,” Journal of Molecular Medicine 90, no. 8 (2012): 925–934. doi:10.1007/s00109-011-0856-x.

“NTP Toxicology and Carcinogenesis Studies of 1-Trans-Delta(9)- Tetrahydrocannabinol (CAS No. 1972-08-3) in F344 Rats and B6C3F1Mice (Gavage Studies),” National Toxicology Program Technical Report Series 446 (1996): 1–317.

A. A. Thomas, L. P. Wallner, V. P. Quinn, J. Slezak, S. K. Van Den Eeden, G. W. Chien, and S. J. Jacobsen, “Association between Cannabis Use and the Risk of Bladder Cancer: Results from the California Men’s Health Study,” Urology 85, iss. 2 (2015): 388–393.

Osteoporosis and osteoarthritis:

N. M. Kogan, E. Melamed, E. Wasserman, B. Raphael, A. Breuer, K. S. Stok, R. Sondergaard, A. V. Escudero, S. Baraghithy, M. Attar-Namdar, S. Friedlander-Barenboim, N. Mathavan, H. Isaksson, R. Mechoulam, R. Müller, A. Bajayo, Y. Gabet, and I. Bab, “Cannabidiol, A Major Nonpsychotropic Cannabis Constituent,

Skin conditions and protection:

Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts,” Journal of Mineral and Bone Research 30, no. 10 (October 2015): 1905–1913.

A. J. Hampson, M. Grimaldi, J. Axelrod, and D. Wink, “Cannabidiol and (−)∆9-Tetrahydrocannabinol Are Neuroprotective Antioxidants,” Proceedings of the National Academy of Sciences of the United States of America 95, no. 14 (1998): 8268–8273.

N. Dobrosi, B. I. Toth, G. Nagy, A. Dozsa, T. Geczy, L. Nagy, C. C. Zouboulis, R. Paus, L. Kovacs, and T. Biro, “Endocannabinoids Enhance Lipid Synthesis and Apoptosis of Human Sebocytes via Cannabinoid Receptor-2-Mediated Signaling,” The FASEB Journal 22, no. 10 (2008): 3685– 3695. doi:10.1096/fj.0604877.

Gastrointestinal conditions:

Zachary Wilmer Reichenbach and Ron Schey, “Cannabinoids and GI Disorders: Endogenous and Exogenous,” Current Treatment Options in Gastroenterology 14, no. 4 (2016): 461–477. doi:10.1007/s11938-016-0110.

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